World J Nephrol Urol

World Journal of Nephrology and Urology, ISSN 1927-1239 print, 1927-1247 online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Nephrol Urol and Elmer Press Inc

Journal website http://www.wjnu.org

Original Article

Volume 2, Number 2, November 2013, pages 70-75

Her-2/Neu Overexpression in Invasive Bladder Carcinoma Among a Cohort of Egyptian Patients

Figures

Figure 1. Her-2/Neu circumferential membrane staining in more than 10% of the tumor cells in different cases of bladder carcinoma, (A) squamous cell carcinoma (DAB, × 100); (B) transitional cell carcinoma with bilharzial cystitis; (C) low grade and (D) high grade transitional cell carcinomas (DAB, × 200).

Figure 2. Her-2/Neu overexpression has a significant direct association with increasing grade of bladder carcinoma.

Table

**Table 1.** Clinicopathological Variables of Invasive Bladder Carcinomas and Their Associations With Her-2/Neu Overexpression
Variable		Her-2/Neu expression		P value
Variable		Negative	Positive	P value
SCC: squamous cell carcinoma; TCC: transitional cell carcinoma; AC: adenocarcinoma. * P value is significant if ≤ 0.05.
Gender
Male	20 (62.5%)	9 (45%)	11(55%)	0.272
Female	12 (37.5%)	3 (25%)	9 (75%)
Histology
SCC	14 (43.8%)	5 (35.7%)	9 (64.3%)	0.317
TCC	13 (40.6%)	6 (47%)	7 (53%)
AC	5 (15.6%)	1 (20%)	4 (80%)
Grade
G1	2 (6.3 %)	2 (100%)	0 (0%)	0.001*
G2	17 (53.1%)	9 (53%)	8 (47%)
G3	13 (40.6%)	1 (7.7%)	12 (92.3%)
Depth of invasion
pT2	10 (31.3%)	8 (80%)	2 (20%)	< 0.001*
pT3	22 (68.7%)	4 (18.2%)	18 (81.8%)
Bilharzial cystitis
Present	13 (40.6%)	5 (38.5%)	8 (61.5%)	0.929
Absent	19 (59.4%)	7 (36.8%)	12 (63.2%)
Total	32 (100%)	12 (37.5%)	20 (62.5%)