World Journal of Nephrology and Urology, ISSN 1927-1239 print, 1927-1247 online, Open Access
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Case Report

Volume 7, Number 3-4, November 2018, pages 73-77

A Case of Myeloma Kidney With Glomerular C3 Deposition

Figures

Figure 1.
Figure 1. Scheme of the complement system: alternative complement pathway is outlined in orange [8].
Figure 2.
Figure 2. Under high magnification: atypical light chain fractured casts “myeloma kidney” with diffuse tubular injury and moderate tubular atrophy, interstitial fibrosis and diffuse interstitial inflammation by lymphocytes, monocytes, occasional plasma cells and scattered neutrophils. Moderate arteriosclerosis was noted.
Figure 3.
Figure 3. Immunofluorescence revealed 3+ staining for lambda in the distribution of the atypical casts (above) with weak granular mesangial staining for C3 (below).
Figure 4.
Figure 4. Electron microscopy showed scattered global mesangial and segmental subendothelial immune deposits.