World J Nephrol Urol

World Journal of Nephrology and Urology, ISSN 1927-1239 print, 1927-1247 online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Nephrol Urol and Elmer Press Inc

Journal website https://www.wjnu.org

Original Article

Volume 12, Number 1, July 2023, pages 1-7

Albumin Loss in Post-Dilution On-Line Hemodiafiltration Compared With Pre-Dilution On-Line Hemodiafiltration and Conventional Hemodialysis

**Table 1.** Age, Body Weight, Water Composition of Patient’s Body, Residual Urination, Duration of Dialysis Session, Months on Conventional Dialysis, and Months on On-Line HD
Patients (a/a)	Age (years)	BW (kg)	Total body water (L)	Duration of dialysis session (h)	Residual urination/24 h (mL)	Months on dialysis	Months on HDF
Body water was determined by Watson formula. BW: body weight; HDF: hemodiafiltration; SD: standard deviation.
1	48	74	42.5	4	500	71	24
2	69	67.5	37.2	4.15	0	258	19
3	56	73	34.8	4	100	54	10
4	57	65	31.6	4.15	150	89	24
5	68	59.5	34.6	4	0	450	10
6	70	70	36.7	4	150	61	10
7	85	84	40.3	4	100	19	9
8	77	85	41.7	4	750	10	4
9	72	69	31.7	4	500	29	8
10	53	79	40.3	4.45	0	417	4
Mean ± SD	65.5 ± 11.03 (median 68.5)	72.6 ± 7.76	37.1 ± 3.76	4.08 ± 0.14		145 ± 158	12.2 ± 7.08 (range 4 - 24)

Table 1. Age, Body Weight, Water Composition of Patient’s Body, Residual Urination, Duration of Dialysis Session, Months on Conventional Dialysis, and Months on On-Line HD

Patients (a/a)

Age (years)

BW (kg)

Total body water (L)

Duration of dialysis session (h)

Residual urination/24 h (mL)

Months on dialysis

Months on HDF

Body water was determined by Watson formula. BW: body weight; HDF: hemodiafiltration; SD: standard deviation.

42.5

500

67.5

37.2

4.15

258

34.8

100

31.6

4.15

150

59.5

34.6

450

36.7

150

40.3

100

41.7

750

31.7

500

40.3

4.45

417

Mean ± SD

65.5 ± 11.03 (median 68.5)

72.6 ± 7.76

37.1 ± 3.76

4.08 ± 0.14

145 ± 158

12.2 ± 7.08 (range 4 - 24)

**Table 2.** Serum Albumin (Before and After Starting On-Line HDF), Dialysate Albumin During On-Line HDF and Conventional Hemodialysis and URR of Patients in Every Group
Patients (a/a)	Serum albumin (g/L)	Dialysate albumin (g/session)	URR (%)	TMP (median)
Group A patients on post-dilution on-line HDF with filter 2.5 m², group B on post-dilution on-line HDF with filter 2.1 m², group C on conventional hemodialysis with filter 2.1 m² and group D on pre-dilution on-line HDF with filter 2.5 m². HD: hemodialysis; HDF: hemodiafiltration; SD: standard deviation; TMP: transmembrane pressure; URR: urea reduction ratio.
1	40	44	2.93	1.46	2.43	1.68	70.4	70	66.2	69.2	173	197	74
2	43	41	4.55	4.55	3.77	1.77	76.5	76.1	75.2	74.7	69	198	63
3	48	42	2.93	1.45	2.51	1.70	76.5	79.2	74.5	76.4	164	108	58
4	40	42	3.08	1.52	1.28	1.79	77.2	77.9	73.5	77.1	171	196	54
5	41	40	4.35	1.45	3.68	1.68	77.6	80	76.5	78.1	77	193	105
6	44	39	4.30	1.46	2.47	1.75	74	73.4	71.4	72.7	176	175	72
7	44	48	1.49	1.43	2.43	1.73	75.6	76.1	75.2	76.2	165	187	71
8	39	41	1.43	2.90	1.22	1.70	74.3	73.2	70.8	70.7	166	167	82
9	42	40	1.46	1.45	1.23	1.65	78	78.6	77.1	79.4	164	112	70
10	40	37	1.72	1.71	2.60	2.01	80.1	78.8	75.8	73.4	122	121	79
Mean ± SD	42.1 ± 2.6	41.4 ± 2.8	2.82 ± 1.19	1.94 ± 0.97	2.36 ± 0.87	1.75 ± 0.097	76.0 ± 2.5	76.3 ± 3.1	73.33 ± 3.3	74.8 ± 3.1
P	Paired t-test (P = NS)	t-test: P(A-B) = 0.05; P(A-C) = NS; P(B-C) = NS; P(A-D) < 0.01; P(B-D) < 0.01; P(C-D) < 0.03	t-test: P(A-C) < 0.05; P(B-C) < 0.05; P = NS for all other correlations	t-test: P(A-B) = NS; P(A-D) < 0.0001; P(B-D) < 0.0001

Table 2. Serum Albumin (Before and After Starting On-Line HDF), Dialysate Albumin During On-Line HDF and Conventional Hemodialysis and URR of Patients in Every Group

Patients (a/a)

Serum albumin (g/L)

Dialysate albumin (g/session)

URR (%)

TMP (median)

Serum albumin during HD

Serum albumin during HDF

Group A

Group B

Group C

Group D

Group A

Group B

Group C

Group D

Group A

Group B

Group D

Group A patients on post-dilution on-line HDF with filter 2.5 m², group B on post-dilution on-line HDF with filter 2.1 m², group C on conventional hemodialysis with filter 2.1 m² and group D on pre-dilution on-line HDF with filter 2.5 m². HD: hemodialysis; HDF: hemodiafiltration; SD: standard deviation; TMP: transmembrane pressure; URR: urea reduction ratio.

2.93

1.46

2.43

1.68

70.4

66.2

69.2

173

197

4.55

3.77

1.77

76.5

76.1

75.2

74.7

198

2.93

1.45

2.51

1.70

76.5

79.2

74.5

76.4

164

108

3.08

1.52

1.28

1.79

77.2

77.9

73.5

77.1

171

196

4.35

1.45

3.68

1.68

77.6

76.5

78.1

193

105

4.30

1.46

2.47

1.75

73.4

71.4

72.7

176

175

1.49

1.43

2.43

1.73

75.6

76.1

75.2

76.2

165

187

1.43

2.90

1.22

1.70

74.3

73.2

70.8

70.7

166

167

1.46

1.45

1.23

1.65

78.6

77.1

79.4

164

112

1.72

1.71

2.60

2.01

80.1

78.8

75.8

73.4

122

121

Mean ± SD

42.1 ± 2.6

41.4 ± 2.8

2.82 ± 1.19

1.94 ± 0.97

2.36 ± 0.87

1.75 ± 0.097

76.0 ± 2.5

76.3 ± 3.1

73.33 ± 3.3

74.8 ± 3.1

Paired t-test (P = NS)

t-test: P(A-B) = 0.05; P(A-C) = NS; P(B-C) = NS; P(A-D) < 0.01; P(B-D) < 0.01; P(C-D) < 0.03

t-test: P(A-C) < 0.05; P(B-C) < 0.05; P = NS for all other correlations

t-test: P(A-B) = NS; P(A-D) < 0.0001; P(B-D) < 0.0001