Severe Hyponatremia and Hypocalcemia in Gitelman Syndrome: A Case Report

Abstract

Gitelman syndrome (GS) is a recessive salt-losing tubulopathy due to a mutation of genes encoding the sodium chloride cotransporters and magnesium channels in the thiazide-sensitive segments of the distal convoluted tubule. In this paper we describe a 69-year-old lady with GS who presented with severe hyponatremia and hypocalcemia which are very rare complications associated with this syndrome. We are discussing the mechanisms involved in the development of these rare manifestations in this case report.

World J Nephrol Urol. 2014;3(2):110-112
doi: http://dx.doi.org/10.14740/wjnu149w