Albumin Loss in Post-Dilution On-Line Hemodiafiltration Compared With Pre-Dilution On-Line Hemodiafiltration and Conventional Hemodialysis

Konstantinos S. Mavromatidis, Irini M. Kalogiannidou, Ploumis S. Passadakis


Background: The purpose of the study was to investigate the amounts of albumin lost in the dialysate in a dialysis session using either a high-flux (on-line hemodiafiltration (HDF)) or a low-flux filter (conventional hemodialysis (HD)).

Methods: The loss of albumin was studied in 10 hemodialyzed patients, with on-line HDF (pre- and post-dilution) and with conventional HD. We determined the albumin loss in the total ultrafiltrate for four different dialysis models.

Results: No change was found in serum albumin levels when switching from conventional HD to on-line HDF. The loss of albumin in on-line HDF post-dilution, with a high-flux filter of 2.5 m2 (group A) was marginally significantly greater than the loss with the same filter with a surface area of 2.1 m2 (group B) (P = 0.05). However, there was no difference in albumin loss when comparing groups A and B with group C (conventional HD) (P = NS). Albumin loss was significantly less in group D (pre-dilution on-line HDF, with filter 2.5 m2 surface area) compared to groups A (P < 0.01), B (P < 0.01) and C (P < 0.03). The urea reduction ratio in each case (groups A, B, C and D) was, on average, > 73.5%, but in group C, it was significantly lower than in groups A and B (P < 0.05). Transmembrane pressure in group D was clearly lower than in groups A and B.

Conclusion: The polyethersulfone filters (polynephron) used in the on-line HDF lost very little albumin in a session (more with post-dilution), but this increased when their surface area and the transmembrane pressure increased. The urea reduction ratio was above the desired target in each model of dialysis using this filter, including both surface areas.

World J Nephrol Urol. 2023;12(1):1-7


On-line HDF; Post-dilution; Pre-dilution; Albumin loss; Polyethersulfone; Conventional hemodialysis

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics






World Journal of Nephrology & Urology, quarterly, ISSN 1927-1239 (print), 1927-1247 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada
© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.