A Case of Collapsing Glomerulopathy Secondary to Romidepsin Therapy in a Patient With Subcutaneous Panniculitis-Like T-Cell Lymphoma

Abstract

We report a case of a 44-year-old female with subcutaneous panniculitis-like T-cell lymphoma, who developed acute renal failure and nephrotic syndrome following treatment with romidepsin. Renal biopsy revealed collapsing variant of focal segmental glomerulosclerosis (FSGS), with good clinical response to high dose steroids. Although there is an association between paraneoplastic glomerulonephritides and lymphoma, in this case the temporal association and response to therapy, despite progression of the lymphoma, favor FSGS secondary to romidepsin therapy. To our knowledge, this is the first reported case of collapsing FSGS secondary to romidepsin therapy.




World J Nephrol Urol. 2014;3(1):41-48
doi: http://dx.doi.org/10.14740/wjnu132w