Association of Hyperuricemia With Carotid Intima-Media Thickness, Albuminuria, Diabetes, Hypertension in Chronic Renal Failure

Abstract

Background: Carotid artery intima-media thickness (CAIMT) measured by B-mode ultrasonography is widely used as a surrogate marker atherosclerosis. Hyperuricemia is also a well recognized risk factor for cardiovascular diseases. This study was done to find out the role of hyperuricemia on CAIMT and albuminuria, diabetes and hypertension in chronic renal failure (CRF) patients.

Methods: 132 CRF patients and 66 age and sex matched healthy controls were included in this study. Out of 132 CRF patients, 35 were hyperuricemic. CAIMT were measured by B-mode ultrasonography. Statistical analyses were done by SPSS (Statistical package for the social Sciences) soft ware (window version 17.0).

Results: Hyperuricemia was independently correlated with CAIMT in CRF patients (P = 0.018). CRF patients with hyperuricemia had significantly higher CAIMT compared to CAIMT of CRF patients without hyperuricemia (P value < 0.001) and healthy controls (P < 0.001). In hyperuricemic CRF patients, prevalence of hypertension (P < 0.001) and diabetes (P = 0.007) was significantly higher than non-hyperuricemic CRF patients.

Conclusions: Hyperuricemia is independently responsible for increased thickening of Carotid artery intima media thickness and also associated with higher level of albuminuria, and higher prevalence of hypertension and diabetes in CRF patients.




doi:10.4021/wjnu14w