Do Levels of SARS-CoV-2 Anti-Spike Antibody Titers After Vaccination Predict Future Infections in Hemodialysis Patients?

Abstract

Background: There are few data on whether higher severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody titers correlate with subsequent infection in the general population, much less in the dialysis patients.

Methods: Fifty-four hemodialysis patients who had antibody titer measured against SARS-CoV-2 after vaccination were retrospectively looked at after 6 months. Rates of subsequent coronavirus disease 2019 (COVID-19) infection were correlated with initial antibody titers.

Results: The mean antibody titer in the patients who subsequently developed SARS-CoV-2 infection was 437 relative fluorescent units (RFU) as compared with mean antibody titer of 1,436 RFU in patients who did not developed infection.

Conclusion: It seems higher antibody titers are in general protective against subsequent infection; however, some patients developed subsequent infection despite having high antibody titers.

World J Nephrol Urol. 2023;12(1):8-10
doi: https://doi.org/10.14740/wjnu439